Α3IA
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α3IA, also known as GTPL4094, is an inverse agonist of the GABA A receptor. It is more selective for the α3 subunit, hence its name.
α3IA, also known as GTPL4094, is an inverse agonist of the GABA A receptor. It is more selective for the α3 subunit, hence its name.
Effects
Agonism of the α3 subunit shows anxiolytic properties. However, by being an inverse agonist, α3IA has the opposite action: it shows anxiogenic properties. This compound also has affinity for the other subunits of the GABA A receptor, but it is more selective for the α3 subunit.
See also
α5IA, an inverse agonist at the α5 subunit of GABA A receptors
References
Text derived from https://en.wikipedia.org/w/index.php?oldid=1332234185 under CC BY-SA 4.0; modifications have been made.