Lesson plan
Abhd3
Alpha/beta hydrolase domain containing 3 (ABHD3; alternative names: lung alpha/beta hydrolase 3, phospholipase ABHD3) is a single pass type II membrane member of the serine hydrolase family of enzymes. The expression of murine ABHD3 is highest in the brain, liver, and kidney. ABHD3 hydrolytic activity is highly specific for medium chain (e.g., dimyristoylphosphatidylcholine) and oxidatively truncated (e.g., azelaoyl PAF) phospholipids. ABHD3-deficient mice are viable, fertile, and possess dramatically elevated medium chain phospholipids in tissues and in blood. Conversely, ectopic expression of ABHD3 prevents the accumulation of oxidized phospholipids in cells.
Article summary
Alpha/beta hydrolase domain containing 3 (ABHD3; alternative names: lung alpha/beta hydrolase 3, phospholipase ABHD3) is a single pass type II membrane member of the serine hydrolase family of enzymes. The expression of murine ABHD3 is highest in the brain, liver, and kidney. ABHD3 hydrolytic activity is highly specific for medium chain (e.g., dimyristoylphosphatidylcholine) and oxidatively truncated (e.g., azelaoyl PAF) phospholipids. ABHD3-deficient mice are viable, fertile, and possess dramatically elevated medium chain phospholipids in tissues and in blood. Conversely, ectopic expression of ABHD3 prevents the accumulation of oxidized phospholipids in cells.
Key claims
No claims recorded.
Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
No sources recorded.
Key claims and bibliography are generated from the same tracked claims and sources as the article page.