ACAP1
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Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1), also called Centaurin β1, is a protein that in humans is encoded by the gene ACAP1 (previously CENTB1). ACAP1 is a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6 belonging to the ADP-ribosylation factor family. It also contains a coiled-coil structural motif, ankyrin repeat (ANK), and a PH domain. The expression of ACAP1 is tissue-specific, with the highest levels observed in the lung and spleen, while the lower levels are found in the heart, kidney, liver, and pancreas.
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1), also called Centaurin β1, is a protein that in humans is encoded by the gene ACAP1 (previously CENTB1). ACAP1 is a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6 belonging to the ADP-ribosylation factor family. It also contains a coiled-coil structural motif, ankyrin repeat (ANK), and a PH domain. The expression of ACAP1 is tissue-specific, with the highest levels observed in the lung and spleen, while the lower levels are found in the heart, kidney, liver, and pancreas. ==Regulation== With the regulation of ARF6, the CENTB1 containing clathrin coat complex functions in two physiological contexts requiring endocytic recycling. Which is integrin recycling, vital for cell migration, and Glut4 recycling, essential for glucose homeostasis. The CENTB1 protein plays an important role in regulating integrin β1 (ITGB1) by facilitating its export from recycling endosomes to the cell surface and ITGB1-dependent cell migration. CENTB1 protein regulates endocytic recycling, which is a process that is essential for diverse cellular function such as nutrient uptake, cell polarity, cell motility, signal transduction, and phagocytosis. As well, CENTB1 facilitates TfR recycling and establishes its role in cargo sorting. It was also found that CENTB1 is a component of a novel clathrin coat complex that regulates stimulation-dependent integrin recycling and insulin-stimulated Glut4 recycling.
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