Aff1
≈ 3 min read
Names in other languages
- DeutschAff1
- EnglishAff1
- EspañolAff1
- FrançaisAff1
- NederlandsAff1
- PortuguêsAff1
- srnAff1
- SvenskaAff1
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
AF4/FMR2 family member 1 is a protein that in humans is encoded by the AFF1 gene. At its same location was a record for a separate PBM1 gene, which has since been withdrawn and considered an alias. It was previously known as AF4 (ALL1-fused gene from chromosome 4). The gene is a member of the AF4/FMR2 (AFF) family, a group of nuclear transcriptional activators which encourage RNA elongation. It is a component of the super elongation complex. The AFF1 protein, and to the same extent AFF4, has multiple functions but is primarily used to assemble the components of the super elongation complex by creating binding surfaces. It is recognized as a proto-oncogene: chromosomal translocations associated with leukemia can fuse this gene with others like KMT2A, producing an uncontrolled activator protein. Translocation creates the fusion protein KMT2A-AFF1 which is the primary oncogenic fusion that sets up the pre-leukemic conditions responsible for driving acute lymphoblastic leukemia.
AF4/FMR2 family member 1 is a protein that in humans is encoded by the AFF1 gene. At its same location was a record for a separate PBM1 gene, which has since been withdrawn and considered an alias. It was previously known as AF4 (ALL1-fused gene from chromosome 4). The gene is a member of the AF4/FMR2 (AFF) family, a group of nuclear transcriptional activators which encourage RNA elongation. It is a component of the super elongation complex. The AFF1 protein, and to the same extent AFF4, has multiple functions but is primarily used to assemble the components of the super elongation complex by creating binding surfaces. It is recognized as a proto-oncogene: chromosomal translocations associated with leukemia can fuse this gene with others like KMT2A, producing an uncontrolled activator protein. Translocation creates the fusion protein KMT2A-AFF1 which is the primary oncogenic fusion that sets up the pre-leukemic conditions responsible for driving acute lymphoblastic leukemia.
Text derived from https://en.wikipedia.org/w/index.php?oldid=1361498244 under CC BY-SA 4.0; modifications have been made.