Lesson plan
Alpl
Alkaline phosphatase, tissue-nonspecific isozyme (TNAP) is an enzyme that in humans is encoded by the ALPL gene. Its chemical formula is:C 2916 H 4587 O 1110 N 707 S 19 P 2 . TNAP catalyses the breakdown of pyrophosphate (an extracellular inhibitor of hydroxyapatite precipitation). It is secreted into the osteoid by osteoblasts to allow bone mineralization to take place.
Article summary
Alkaline phosphatase, tissue-nonspecific isozyme (TNAP) is an enzyme that in humans is encoded by the ALPL gene. Its chemical formula is:C 2916 H 4587 O 1110 N 707 S 19 P 2 . TNAP catalyses the breakdown of pyrophosphate (an extracellular inhibitor of hydroxyapatite precipitation). It is secreted into the osteoid by osteoblasts to allow bone mineralization to take place.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.