Araf

Araf can refer to: * ARAF, a gene * "Araf", a Welsh word meaning "slow". * Autorité de Régulation des Activités Ferroviaires, a regulatory body in France * Araf (film) * The All-Russia Athletic Federation * Al-A'raf (realm of afterlife), the Muslim sheol or borderland between heaven and hell for those who are, from incapacity, neither morally bad nor morally good * Al-A'raf (surah) 7th chapter (sūrah) of the Qur'an

Serine/threonine-protein kinase A-Raf, or simply A-Raf, is an enzyme that in humans is encoded by the ARAF gene. It belongs to the Raf kinase family of serine/threonine-specific protein kinases, which also includes Raf-1 and B-Raf. A-Raf is involved in the MAPK/ERK pathway, where it contributes to cell signaling processes that regulate proliferation, survival, and differentiation. Compared to Raf-1 and B-Raf, A-Raf is less well studied and exhibits distinct structural and regulatory features, including low kinase activity and alternative splicing in cancer. In addition to its role in MAPK signaling, A-Raf has functions in apoptosis suppression, cancer metabolism, and endocytic trafficking. ==External links== PDBe-KB provides an overview of all the structure information available in the PDB for Human Serine/threonine-protein kinase A-Raf

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