Lesson plan

AREsite

AREsite is a database of AU-rich elements (ARE) in vertebrate mRNA 3'-untranslated regions (UTRs). AU-rich elements are involved in the control of gene expression. They are the most common determinant of RNA stability in mammalian cells. The most recent version of AREsite is called AREsite 2. It represents an update that allows for more detailed analysis of ARE, GRE, and URE (AU, GU, and U-rich elements).

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Article summary

AREsite is a database of AU-rich elements (ARE) in vertebrate mRNA 3'-untranslated regions (UTRs). AU-rich elements are involved in the control of gene expression. They are the most common determinant of RNA stability in mammalian cells. The most recent version of AREsite is called AREsite 2. It represents an update that allows for more detailed analysis of ARE, GRE, and URE (AU, GU, and U-rich elements).

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Discussion questions

  1. Summarise the article in your own words. Which single claim would you verify first, and why?
  2. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
  3. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

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Key claims and bibliography are generated from the same tracked claims and sources as the article page.