Lesson plan
BICD2
Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene. This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. Mutations in BICD2 are associated with spinal muscular atrophy with lower extremity predominance type 2A and type 2B.
Article summary
Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene. This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. Mutations in BICD2 are associated with spinal muscular atrophy with lower extremity predominance type 2A and type 2B.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.