Lesson plan

C+-probability

In statistics, a c + -probability is the probability that a contrast variable obtains a positive value. Using a replication probability, the c + -probability is defined as follows: if we get a random draw from each group (or factor level) and calculate the sampled value of the contrast variable based on the random draws, then the c + -probability is the chance that the sampled values of the contrast variable are greater than 0 when the random drawing process is repeated infinite times. The c + -probability is a probabilistic index accounting for distributions of compared groups (or factor levels). The c + -probability and SMCV are two characteristics of a contrast variable. There is a link between SMCV and c + -probability. The SMCV and c + -probability provides a consistent interpretation to the strength of comparisons in contrast analysis. When only two groups are involved in a comparison, the c + -probability becomes d + -probability which is the probability that the difference of values from two groups is positive. To some extent, the d + -probability (especially in the independent situations) is equivalent to the well-established probabilistic index P(X > Y). Historically, the index P(X > Y) has been studied and applied in many areas. The c + -probability and d + -probability have been used for data analysis in high-throughput experiments and biopharmaceutical research.

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Article summary

In statistics, a c + -probability is the probability that a contrast variable obtains a positive value. Using a replication probability, the c + -probability is defined as follows: if we get a random draw from each group (or factor level) and calculate the sampled value of the contrast variable based on the random draws, then the c + -probability is the chance that the sampled values of the contrast variable are greater than 0 when the random drawing process is repeated infinite times. The c + -probability is a probabilistic index accounting for distributions of compared groups (or factor levels). The c + -probability and SMCV are two characteristics of a contrast variable. There is a link between SMCV and c + -probability. The SMCV and c + -probability provides a consistent interpretation to the strength of comparisons in contrast analysis. When only two groups are involved in a comparison, the c + -probability becomes d + -probability which is the probability that the difference of values from two groups is positive. To some extent, the d + -probability (especially in the independent situations) is equivalent to the well-established probabilistic index P(X > Y). Historically, the index P(X > Y) has been studied and applied in many areas. The c + -probability and d + -probability have been used for data analysis in high-throughput experiments and biopharmaceutical research.

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Discussion questions

  1. Summarise the article in your own words. Which single claim would you verify first, and why?
  2. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
  3. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

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