CCDC142

The coiled-coil domain containing 142 (CCDC142) is a gene which in humans encodes the CCDC142 protein. The CCDC142 gene is located on chromosome 2 (at 2p13), spans 4339 base pairs and contains 9 exons. The gene codes for the coiled-coil domain containing protein 142 (CCDC142), whose function is not yet well understood. There are two known isoforms of CCDC142. CCDC142 proteins produced from these transcripts range in size from 743 to 665 amino acids and contain signals suggesting protein movement between the cytosol and nucleus. Homologous CCDC142 genes are found in many animals including vertebrates and invertebrates but not fungus, plants, protists, archea, or bacteria. Although the function of this protein is not well understood, it contains a coiled-coil domain and a RINT1_TIP1 motif located within the coiled-coil domain.

The coiled-coil domain containing 142 (CCDC142) is a gene which in humans encodes the CCDC142 protein. The CCDC142 gene is located on chromosome 2 (at 2p13), spans 4339 base pairs and contains 9 exons. The gene codes for the coiled-coil domain containing protein 142 (CCDC142), whose function is not yet well understood. There are two known isoforms of CCDC142. CCDC142 proteins produced from these transcripts range in size from 743 to 665 amino acids and contain signals suggesting protein movement between the cytosol and nucleus. Homologous CCDC142 genes are found in many animals including vertebrates and invertebrates but not fungus, plants, protists, archea, or bacteria. Although the function of this protein is not well understood, it contains a coiled-coil domain and a RINT1_TIP1 motif located within the coiled-coil domain. of the number of millions of years since the date of divergence of Homo sapiens lineage and the lineage of the species in which the ortholog is seen. The points on the graph are calculated according to m/100 = –ln(1–n/100), where m is the total number of amino acid changes occurred in a 100-amino-acid segment of a protein and n is the observed number of amino acid changes per 100 residues compared to the Homo sapiens protein sequence.

Structure prediction

Secondary structure of CCDC142 contains only α-helices as predicted by the Quick2D and Phyre2 programs . It is predicted that CCDC142 contains eight conserved α-helices, with six located in the coiled-coil region of the protein. The predicted tertiary structure of CCDC142 contains a large coiled-coil domain from amino acids 308–719. of -.75 (measured on a scale of −5 to 2, with higher values equating higher confidence) and a cluster density of .375 (on a scale of 0 to 1, with higher values indicating greater protein prediction coverage). The C-score takes into account both significance of the model's structure and the quality of the prediction coverage from other proteins. |423x423px|none

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