CD40
≈ 2 min read
Names in other languages
- DeutschCD40
- EnglishCD40
- FrançaisCD40
- glCD40
- NederlandsCD40
- PolskiCD40
- РусскийCD40
- srnCD40
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. Activated CD4+ T cells primarily exhibit its ligand CD40L/CD154 to antigen-presenting cells including dendritic cells (DCs), B cells, macrophages, classical and non-classical monocytes, on a variety of non-immune cells including platelets and endothelial cells, and on several types of tumor cells. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency.
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. Activated CD4+ T cells primarily exhibit its ligand CD40L/CD154 to antigen-presenting cells including dendritic cells (DCs), B cells, macrophages, classical and non-classical monocytes, on a variety of non-immune cells including platelets and endothelial cells, and on several types of tumor cells. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency.
Text derived from https://en.wikipedia.org/w/index.php?oldid=1368836374 under CC BY-SA 4.0; modifications have been made.