CD79
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The CD79 receptor complex, also known as CD79A:CD79B or Igα:Igβ, is a heterodimeric signaling component of the B-cell receptor (BCR) complex. This transmembrane heterodimer consists of the B-cell antigen receptor complex-associated protein alpha chain (CD79A/Igα) and the B-cell antigen receptor complex-associated protein beta chain (CD79B/Igβ). The CD79 complex is expressed almost exclusively on B cells and B-cell neoplasms, making it valuable for differential diagnosis of B-cell malignancies from T-cell or myeloid neoplasms. CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the mb-1 gene that is located on chromosome 19, and CD79b is encoded by the B29 gene that located on chromosome 17. Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3-generated signal transduction observed during T cell receptor activation on T cells.
The CD79 receptor complex, also known as CD79A:CD79B or Igα:Igβ, is a heterodimeric signaling component of the B-cell receptor (BCR) complex. This transmembrane heterodimer consists of the B-cell antigen receptor complex-associated protein alpha chain (CD79A/Igα) and the B-cell antigen receptor complex-associated protein beta chain (CD79B/Igβ). The CD79 complex is expressed almost exclusively on B cells and B-cell neoplasms, making it valuable for differential diagnosis of B-cell malignancies from T-cell or myeloid neoplasms. CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the mb-1 gene that is located on chromosome 19, and CD79b is encoded by the B29 gene that located on chromosome 17. Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3-generated signal transduction observed during T cell receptor activation on T cells.
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