CDC73
≈ 1 min read
Names in other languages
No names in other languages are held for this entry yet.
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
Parafibromin, also called Cell division cycle 73, is a protein which in humans is encoded by the CDC73 gene. CDC73 is part of the PAF1 complex.
Parafibromin, also called Cell division cycle 73, is a protein which in humans is encoded by the CDC73 gene. CDC73 is part of the PAF1 complex. ==Function== Parafibromin, LEO1, PAF1, and CTR9 form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. ==Clinical significance== Mutations in the CDC73 gene are associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid carcinomas. ==See also== Primary hyperparathyroidism Osteitis fibrosa cystica ==References== ==External links== GeneReviews/NCBI/NIH/UW entry on CDC73-Related Disorders ==Further reading==
Text derived from https://en.wikipedia.org/w/index.php?oldid=1375104164 under CC BY-SA 4.0; modifications have been made.