CFAP92
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Uncharacterized protein CFAP92 is a protein that in humans is encoded by the gene CFAP92 (previously KIAA1257). While the function of CFAP92 remains unclear, some early research has suggested it may activate steroidogenic factor 1 (also known as NR5A1), a multifunctional transcription factor involved in the development of adrenal and gondal tissues.
Uncharacterized protein CFAP92 is a protein that in humans is encoded by the gene CFAP92 (previously KIAA1257). While the function of CFAP92 remains unclear, some early research has suggested it may activate steroidogenic factor 1 (also known as NR5A1), a multifunctional transcription factor involved in the development of adrenal and gondal tissues.
Gene
In humans the gene KIAA1257 is located on chromosome 3q21.3. It spans 122 kilobasepairs (kBp) and contains 22 exons. It is flanked by Ras-related protein Rab-43 and several pseudogenes and on the opposite strand Acyl CoA dehydrogenase family member 9 (ACAD9) and EF-hand and coiled-coil domain containing 1 (EFCC1).
Transcripts
The exons of KIAA1257 are alternatively spliced into 17 different isoforms (Table 1). Isoform X1 encodes the longest protein product and isoform X4 is the most common variant translated. Both the 5' and 3' UTR's are capable of forming stem loop structures that could serve as binding site for RNA-binding proteins. Table 1
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