CHD4
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Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex.
Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex. ==Clinical== Mutations in this gene have been associated with a condition known as Sifrim-Hitz-Weiss syndrome. This condition is characterized by Brain anomalies Macrocephaly Deafness Ophthalmic abnormalities Dysmorphic features Congenital heart defects Hypogonadism in males Skeletal and limb anomalies Global developmental delay Mild to moderate intellectual disability
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