CIART
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Circadian Associated Repressor of Transcription (also known as Chrono or Gm129) is a protein that in humans is encoded by the CIART gene. The CIART protein functions as a transcriptional repressor of the BMAL1-CLOCK complex. In addition to negatively regulating the circadian transcription-translation feedback loop (TTFL), the CIART protein is involved with stress metabolism response in response to cortisol. New research implicates that CIART protein and glucocorticoid receptors form a complex and regulate response to stress in a circadian manner.
Circadian Associated Repressor of Transcription (also known as Chrono or Gm129) is a protein that in humans is encoded by the CIART gene. The CIART protein functions as a transcriptional repressor of the BMAL1-CLOCK complex. In addition to negatively regulating the circadian transcription-translation feedback loop (TTFL), the CIART protein is involved with stress metabolism response in response to cortisol. New research implicates that CIART protein and glucocorticoid receptors form a complex and regulate response to stress in a circadian manner.
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