Lesson plan
Cointegrate
A cointegrate is the intermediate molecule between donor DNA and target DNA covalently bind during the formation of a Holliday junction. Transposons elements are DNA sequences that can change its position within the genome, sometimes creating reversing mutations. A number of bacterial transposons, especially those related to Tn3 Tn552, encodes two recombinases that participate in their transposition to other DNA. The initial step that mediated this process involve the formation of cointegrate. The cointegrate is formed between the transposon containing donor DNA and the target molecule. In this transpositional intermediate, the donor and target DNAs are joined together by copies of the duplicated transposon, one copy occurring at each donor–target junction.
Article summary
A cointegrate is the intermediate molecule between donor DNA and target DNA covalently bind during the formation of a Holliday junction. Transposons elements are DNA sequences that can change its position within the genome, sometimes creating reversing mutations. A number of bacterial transposons, especially those related to Tn3 Tn552, encodes two recombinases that participate in their transposition to other DNA. The initial step that mediated this process involve the formation of cointegrate. The cointegrate is formed between the transposon containing donor DNA and the target molecule. In this transpositional intermediate, the donor and target DNAs are joined together by copies of the duplicated transposon, one copy occurring at each donor–target junction.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.