Lesson plan
COMPASS complex
Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. Since it was first identified in 2001, other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans. The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans. They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines. The COMPASS complex is an example of a trithorax-group protein. The MLL1/SET domain associated with the COMPASS complex have crystal structure. The gene Cps50 coordinates the construction of COMPASS.
Article summary
Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. Since it was first identified in 2001, other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans. The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans. They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines. The COMPASS complex is an example of a trithorax-group protein. The MLL1/SET domain associated with the COMPASS complex have crystal structure. The gene Cps50 coordinates the construction of COMPASS.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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