Lesson plan
Contact normalization
Contact normalization is a process by which intercellular junctions mediate signals that allow normal cells to inhibit the transformed growth of neighboring tumor cells. Intimate junctional contact between tumor cells and normal cells is needed for this form of growth control. Contact normalization describes the ability of nontransformed cells to normalize the growth of neighboring cancer cells. This is a very widespread and powerful phenomenon. Tumor cells need to overcome this form of growth inhibition before they can become malignant or metastatic. Induction of a select set of genes has been associated with the ability of cancer cells to escape contact normalization. These include podoplanin (PDPN), vascular endothelial growth factor receptor 2/kinase insert domain receptor (VEGFR2/KDR), and transmembrane protein 163 (TMEM163) receptors.
Article summary
Contact normalization is a process by which intercellular junctions mediate signals that allow normal cells to inhibit the transformed growth of neighboring tumor cells. Intimate junctional contact between tumor cells and normal cells is needed for this form of growth control. Contact normalization describes the ability of nontransformed cells to normalize the growth of neighboring cancer cells. This is a very widespread and powerful phenomenon. Tumor cells need to overcome this form of growth inhibition before they can become malignant or metastatic. Induction of a select set of genes has been associated with the ability of cancer cells to escape contact normalization. These include podoplanin (PDPN), vascular endothelial growth factor receptor 2/kinase insert domain receptor (VEGFR2/KDR), and transmembrane protein 163 (TMEM163) receptors.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.