Creatinase

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In enzymology, creatinase ( ), also known as creatine amidinohydrolase, is classified as a hydrolase enzyme, acting on carbon-nitrogen bonds in linear amidines. Specifically, this enzyme breaks the amidino C-N bond in creatine, producing sarcosine and urea. Creatinase activity has been described in several bacteria species, most notably Pseudomonas putida, where the enzyme plays a key role in the metabolism of creatine as a nitrogen and carbon source.

In enzymology, creatinase ( ), also known as creatine amidinohydrolase, is classified as a hydrolase enzyme, acting on carbon-nitrogen bonds in linear amidines. Specifically, this enzyme breaks the amidino C-N bond in creatine, producing sarcosine and urea. Creatinase activity has been described in several bacteria species, most notably Pseudomonas putida, where the enzyme plays a key role in the metabolism of creatine as a nitrogen and carbon source. (H2N)(HN)CN(CH3)CH2CO2H + H2O CH3N(H)CH2CO2H + CO(NH2)2 creatine + H 2 O \rightleftharpoons sarcosine + urea

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