Lesson plan
CtRNA
In molecular biology ctRNA (counter-transcribed RNA) is a plasmid encoded noncoding RNA that binds to the mRNA of and causes translational inhibition. ctRNA is encoded by plasmids and functions in rolling circle replication to maintain a low copy number. In Corynebacterium glutamicum, it achieves this by antisense pairing with the mRNA of , a replication initiation protein. In Enterococcus faecium the plasmid pJB01 contains three open reading frames, copA, , and . The pJB01 ctRNA is coded on the opposite strand from the / intergenic region and partially overlaps an atypical ribosome binding site for .
Article summary
In molecular biology ctRNA (counter-transcribed RNA) is a plasmid encoded noncoding RNA that binds to the mRNA of and causes translational inhibition. ctRNA is encoded by plasmids and functions in rolling circle replication to maintain a low copy number. In Corynebacterium glutamicum, it achieves this by antisense pairing with the mRNA of , a replication initiation protein. In Enterococcus faecium the plasmid pJB01 contains three open reading frames, copA, , and . The pJB01 ctRNA is coded on the opposite strand from the / intergenic region and partially overlaps an atypical ribosome binding site for .
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.