CyaA
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Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and released in the host's respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CyaA plays a particular role in the early phases of airway colonization. It is able to instantly ablate the bactericidal oxidative burst, along with the opsonophagocytic killing capacities of neutrophils and macrophages. As a result, it enables establishment of Bordetella infection of airway mucosa and promotes immune evasion of B. pertussis, by affecting the host's immune cells.
Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and released in the host's respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CyaA plays a particular role in the early phases of airway colonization. It is able to instantly ablate the bactericidal oxidative burst, along with the opsonophagocytic killing capacities of neutrophils and macrophages. As a result, it enables establishment of Bordetella infection of airway mucosa and promotes immune evasion of B. pertussis, by affecting the host's immune cells.
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