Cyclen
≈ 1 min read
Names in other languages
No names in other languages are held for this entry yet.
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
Cyclen (1,4,7,10-tetraazacyclododecane) is an aza-crown ether with the formula (CH 2 CH 2 NH) 4 . It is a white solid. It forms coordination complexes with metal cations and is used to synthesize the chelating agent DOTA which has several medical applications. Being structurally simple, symmetrical, and polyfunctional, cyclen has been widely investigated.
Cyclen (1,4,7,10-tetraazacyclododecane) is an aza-crown ether with the formula (CH 2 CH 2 NH) 4 . It is a white solid. It forms coordination complexes with metal cations and is used to synthesize the chelating agent DOTA which has several medical applications. Being structurally simple, symmetrical, and polyfunctional, cyclen has been widely investigated. ==Coordination complexes== [[File:CSD CIF JIKJUI.jpg|thumb|left|Structure of [Ni(cyclen)(OH 2 ) 2 ] 2+ . Color code: O = red, N = blue, Ni = dark blue, white = H, gray = C. ]] Coordination complexes of cyclen have been studied extensively. With a 12-membered C8N4 ring, it tends to bind to four contiguous sites on octahedral metal centers, forming four 5-membered chelate rings (see figure). Cyclen also forms "bis complexes", e.g. of the type [Ln(cyclen) 2 ] 3+ where Ln = lanthanide. ==Related compounds== The cyclam ligands are also tetraaza macrocycles but consist of a more flexible C 10 N 4 ring. ==Further reading==
Text derived from https://en.wikipedia.org/w/index.php?oldid=1367976416 under CC BY-SA 4.0; modifications have been made.