Lesson plan

DOTFE

DOTFE, also known as 4-(2,2,2-trifluoroethyl)-2,5-dimethoxyamphetamine, is a drug of the phenethylamine, amphetamine, and DOx families. It is a close analogue of known psychedelics like the DOx psychedelic DOTFM and the 2C psychedelics 2C-TFE and 2C-TFM. The drug was predicted to bind to the serotonin 5-HT 2A receptor, with a predicted affinity (K i ) of 50 nM. It was inactive in humans at doses of up to 3 mg, but higher doses were not assessed. DOTFE is expected to be a potent psychedelic at active doses. It was first described in the scientific literature by at least 1999. DOTFE was evaluated in humans by Daniel Trachsel, with these reports published in 2012 and 2013.

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Article summary

DOTFE, also known as 4-(2,2,2-trifluoroethyl)-2,5-dimethoxyamphetamine, is a drug of the phenethylamine, amphetamine, and DOx families. It is a close analogue of known psychedelics like the DOx psychedelic DOTFM and the 2C psychedelics 2C-TFE and 2C-TFM. The drug was predicted to bind to the serotonin 5-HT 2A receptor, with a predicted affinity (K i ) of 50 nM. It was inactive in humans at doses of up to 3 mg, but higher doses were not assessed. DOTFE is expected to be a potent psychedelic at active doses. It was first described in the scientific literature by at least 1999. DOTFE was evaluated in humans by Daniel Trachsel, with these reports published in 2012 and 2013.

Key claims

  1. publication date: 2012 — source: Wikipedia · confidence 0.95

Discussion questions

  1. Summarise the article in your own words. Which single claim would you verify first, and why?
  2. The record states that the publication date is "2012". What evidence would count against this claim?
  3. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
  4. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

Bibliography

  1. Wikipedia https://en.wikipedia.org/w/index.php?oldid=1366874460

Key claims and bibliography are generated from the same tracked claims and sources as the article page.