Lesson plan

Eoxin E4

Eoxin E 4 (EXE 4 ), also known as 14,15-leukotriene E 4 , is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form (i.e. 15(S)-HpETE). This product is then converted serially to EXA 4 , EXC 4 , EXD 4 , and EXE 4 by LTC 4 synthase, an unidentified gamma-glutamyltransferase, and an unidentified dipeptidase, respectively, in a pathway which appears similar if not identical to the pathway which forms leukotrienes, i.e. LTA 4 , LTC 4 , LTD 4 , and LTE 4 . This pathway is schematically shown as follows: EXA 4 is viewed as an intracellular-bound, short-lived intermediate which is rapidly metabolized to the downstream eoxins. The eoxins downstream of EXA 4 are secreted from their parent cells and, it is proposed but not yet proven, serve to regulate allergic responses and the development of certain cancers (see eoxins).

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Article summary

Eoxin E 4 (EXE 4 ), also known as 14,15-leukotriene E 4 , is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form (i.e. 15(S)-HpETE). This product is then converted serially to EXA 4 , EXC 4 , EXD 4 , and EXE 4 by LTC 4 synthase, an unidentified gamma-glutamyltransferase, and an unidentified dipeptidase, respectively, in a pathway which appears similar if not identical to the pathway which forms leukotrienes, i.e. LTA 4 , LTC 4 , LTD 4 , and LTE 4 . This pathway is schematically shown as follows: EXA 4 is viewed as an intracellular-bound, short-lived intermediate which is rapidly metabolized to the downstream eoxins. The eoxins downstream of EXA 4 are secreted from their parent cells and, it is proposed but not yet proven, serve to regulate allergic responses and the development of certain cancers (see eoxins).

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