Factor H
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Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system, particularly the alternative pathway. Factor H is a large molecule with a molecular weight of approximately 155 kilodaltons and circulates in human blood plasma at concentrations typically ranging from 200–300 micrograms per milliliter.
Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system, particularly the alternative pathway. Factor H is a large molecule with a molecular weight of approximately 155 kilodaltons and circulates in human blood plasma at concentrations typically ranging from 200–300 micrograms per milliliter. ==Recombinant production== Biologically active Factor H has been produced by Ralf Reski and coworkers in the moss bioreactor, in a process called molecular farming. Large quantities of biologically active human Factor H, potentially suitable for therapeutic purposes, were produced using a synthetic codon-optimised gene expressed in the yeast expression host, Pichia pastoris. OMIM entries on Atypical Hemolytic-Uremic Syndrome
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