Fermt2

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene. Kindlin-2 is the first of the kindlin protein to be discovered in 1994. It was detected in a screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein.

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene. Kindlin-2 is the first of the kindlin protein to be discovered in 1994. It was detected in a screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein. ==Role in health and diseases== Loss of kindlin-2 in mice leads to peri-implantation lethality. Kindlin-2 is highly expressed in activated myofibroblasts for regulation of focal adhesion formation. Deletion of Kindlin-2 retards insulin secretion and reduces β-cell mass in mice. Elevated kindlin-2 expression was observed in tubular intestinal fibrosis of the kidney, a condition is characterized by massive expansion of the cortical interstitium, conversion of fibroblasts into myofibroblasts and progressive EMT of tubular epithelial cells. Kindlin-2 is required for angiogenesis and blood vessel homeostasis. Kindlin-2 can exert tumor-promoting or tumor-inhibiting functions based on tumor-type-dependent. FERMT2 modulates the Alzheimer's Disease risk by regulating APP metabolism and Aβ peptide production. FERMT2 Info with links in the Cell Migration Gateway

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