Fuzzy complex
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structure of the cyclin-dependent kinase inhibitor Sic1 with the ubiquitin ligase Cdc4 (grey). Out of the nine phosphorylation sites of Sic 1 (spheres) the contacts with T45 and S76 are shown (orange and blue). transcription factor (orange) connects the homeodomain with the Extradenticle homeodomain (blue) (PDB code 1bi). Alternative splicing modulates the length of the fuzzy region and thus its DNA (grey) binding affinity. Other regulatory fuzzy regions of Ultrabithorax are also shown by dotted lines. Fuzzy complexes are protein complexes, where structural ambiguity or multiplicity exists and is required for biological function. Alteration, truncation or removal of conformationally ambiguous regions impacts the activity of the corresponding complex. Fuzzy complexes are generally formed by intrinsically disordered proteins. Structural multiplicity usually underlies functional multiplicity of protein complexes following a fuzzy logic. Distinct binding modes of the nucleosome are also regarded as a special case of fuzziness.
structure of the cyclin-dependent kinase inhibitor Sic1 with the ubiquitin ligase Cdc4 (grey). Out of the nine phosphorylation sites of Sic 1 (spheres) the contacts with T45 and S76 are shown (orange and blue). transcription factor (orange) connects the homeodomain with the Extradenticle homeodomain (blue) (PDB code 1bi). Alternative splicing modulates the length of the fuzzy region and thus its DNA (grey) binding affinity. Other regulatory fuzzy regions of Ultrabithorax are also shown by dotted lines. Fuzzy complexes are protein complexes, where structural ambiguity or multiplicity exists and is required for biological function. Alteration, truncation or removal of conformationally ambiguous regions impacts the activity of the corresponding complex. Fuzzy complexes are generally formed by intrinsically disordered proteins. Structural multiplicity usually underlies functional multiplicity of protein complexes following a fuzzy logic. Distinct binding modes of the nucleosome are also regarded as a special case of fuzziness.
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