G418

Article summary

{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 461115152 | ImageFile = Geneticin.svg | ImageClass = skin-invert-image | ImageSize = 160 | IUPACName = (1S,2S,3R,4S,6R)-4,6-Diamino-2-hydroxycyclohexane-1,3-diyl 1-(3-amino-3-deoxy-4-C-methyl-β- L -arabinopyranoside) 3-(2-amino-2,7-dideoxy- D -glycero-α- D -gluco-heptopyranoside) | SystematicName = (2R,3S,4R,5R,6S)-5-Amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-[(1R)-1-hydroxyethyl]oxane-3,4-diol | OtherNames = Geneticin, 6'-deamino-6'-hydroxy-gentamicin B 1 O-2-Amino-2,7-didesoxy- D -glycero-α- D -gluco-heptopyranosyl-(1→4)-O-(3-desoxy-4-C-methyl-3-(methylamino)-β- L -arabinopyranosyl- (1→6))- D -streptamin |Section1= |Section2= |Section3= |Section4= |Section5= |Section6= |Section7= |Section8= }} G418 (genericized trade name geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. It is most commonly supplied as a sulfate or disulfate salt. G418 is commonly used in laboratory research to select genetically engineered cells. Resistance to G418 is conferred by an aminoglycoside-3'-phosphotransferase (APH(3')).…

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