Lesson plan
Grid2
Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ 2 , is a protein that in humans is encoded by the GRID2 gene. This protein together with GluD1 belongs to the delta receptor subtype of ionotropic glutamate receptors. They possess 14–24% sequence homology with AMPA, kainate, and NMDA subunits, but, despite their name, have been found not to directly promote neuronal activation in response to glutamate or various other glutamate agonists. delta iGluRs have long been considered orphan receptors as their endogenous ligand was unknown. They are now believed to bind glycine and D-serine but these do not result in channel opening.
Article summary
Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ 2 , is a protein that in humans is encoded by the GRID2 gene. This protein together with GluD1 belongs to the delta receptor subtype of ionotropic glutamate receptors. They possess 14–24% sequence homology with AMPA, kainate, and NMDA subunits, but, despite their name, have been found not to directly promote neuronal activation in response to glutamate or various other glutamate agonists. delta iGluRs have long been considered orphan receptors as their endogenous ligand was unknown. They are now believed to bind glycine and D-serine but these do not result in channel opening.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
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- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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