Lesson plan
HPG80
hPG80 refers to the extracellular and oncogenic version of progastrin. This name first appeared in a scientific publication in January 2020. Until that date, scientific publications only mention 'progastrin', without necessarily explicitly specifying whether it is intracellular (in the context of digestion) or extracellular (circulating and detectable in plasma) in the tumor pathological setting. For more clarity, the remainder of this article uses exclusively the name hPG80 to refer to extracellular progastrin. A link between this protein and cancer has been known for more than 30 years. hPG80 is involved in most of the biological functions that ensure the existence of cancer. The peptide is secreted by tumor cells and found in the plasma of cancer patients from early stages. It then has functions that are independent of digestion and totally different from progastrin and its only role as an intracellular precursor of gastrin.
Article summary
hPG80 refers to the extracellular and oncogenic version of progastrin. This name first appeared in a scientific publication in January 2020. Until that date, scientific publications only mention 'progastrin', without necessarily explicitly specifying whether it is intracellular (in the context of digestion) or extracellular (circulating and detectable in plasma) in the tumor pathological setting. For more clarity, the remainder of this article uses exclusively the name hPG80 to refer to extracellular progastrin. A link between this protein and cancer has been known for more than 30 years. hPG80 is involved in most of the biological functions that ensure the existence of cancer. The peptide is secreted by tumor cells and found in the plasma of cancer patients from early stages. It then has functions that are independent of digestion and totally different from progastrin and its only role as an intracellular precursor of gastrin.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
No sources recorded.
Key claims and bibliography are generated from the same tracked claims and sources as the article page.