IGH@
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IGH (or derivative) may refer to: * Idiopathic guttate hypomelanosis, a dermatological condition * Igh (trigraph), used in Irish orthography * Immunoglobulin heavy chain (IgH), the large polypeptide subunit of an antibody ** IGH@, the Immunoglobulin heavy locus, in biology * Institut IGH, a Croatian company * Internal geared hubs, used on bicycles * Inver Grove Heights, Minnesota, U.S.
Immunoglobulin heavy locus, also known as IGH@, is a region on human chromosome 14 that contains many gene segments for the heavy chains of human antibodies (or immunoglobulins). The @ notation indicates its designation as a gene cluster: IGH@ is a collection of many gene segments. Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments.
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