Insrr
≈ 1 min read
Names in other languages
- DeutschInsrr
- EnglishInsrr
- EspañolInsrr
- FrançaisInsrr
- NederlandsInsrr
- PortuguêsInsrr
- srnInsrr
- SvenskaInsrr
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.
Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.
Function
The encoded protein, commonly abbreviated IRR, is an orphan receptor and one of three receptor tyrosine kinases in the insulin receptor family, alongside the insulin receptor and insulin-like growth factor 1 receptor. No endogenous peptide or protein ligand is known for IRR. In experimental systems, extracellular pH above approximately 7.9 activates the receptor and triggers autophosphorylation. The Human Protein Atlas classifies INSRR RNA expression as cell type enhanced in renal collecting-duct intercalated cells. In rodents, IRR has been localized to non-A intercalated cells; a rat study reported basolateral localization in type B intercalated cells of the cortical collecting duct. In mice, inactivation of Insrr impairs urinary bicarbonate excretion following alkali loading, supporting a role for the receptor in renal acid–base homeostasis. A 2023 cryo-electron microscopy study of the human IRR ectodomain, combined with mutagenesis and cell-based assays, supported a model in which alkaline pH produces electrostatic repulsion involving pH-sensitive motifs at an interprotomer interface, disrupting the autoinhibited state and promoting a scissor-like rotation into a T-shaped active conformation.
References
Further reading
Text derived from https://en.wikipedia.org/w/index.php?oldid=1378075759 under CC BY-SA 4.0; modifications have been made.