Lesson plan
Interface hepatitis
showing interface hepatitis in a liver biopsy Interface hepatitis, formerly known as piecemeal necrosis, nibbling necrosis, and interface necrosis, describes the death of liver cells (hepatocytes) at the lobular-portal-interface, which occurs cell-by-cell (hence "piecemeal"), producing an irregular appearance. Since the underlying mechanism of liver cell death is apoptosis and not necrosis, the term "interface hepatitis" is considered less misleading. Interface hepatitis is characterized by infiltration of lymphocytes into the adjacent parenchyma, and with destruction of individual hepatocytes along the edges of the portal tract. It has been found to occur in chronic hepatitis, particularly in the chronic forms of viral hepatitis, autoimmune hepatitis, and drug-induced liver injury.
Article summary
showing interface hepatitis in a liver biopsy Interface hepatitis, formerly known as piecemeal necrosis, nibbling necrosis, and interface necrosis, describes the death of liver cells (hepatocytes) at the lobular-portal-interface, which occurs cell-by-cell (hence "piecemeal"), producing an irregular appearance. Since the underlying mechanism of liver cell death is apoptosis and not necrosis, the term "interface hepatitis" is considered less misleading. Interface hepatitis is characterized by infiltration of lymphocytes into the adjacent parenchyma, and with destruction of individual hepatocytes along the edges of the portal tract. It has been found to occur in chronic hepatitis, particularly in the chronic forms of viral hepatitis, autoimmune hepatitis, and drug-induced liver injury.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.