Jund
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Names in other languages
- DeutschJund
- EnglishJund
- EspañolJund
- FrançaisJund
- NederlandsJund
- PortuguêsJund
- srnJund
- SvenskaJund
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
Transcription factor JunD is a protein that in humans is encoded by the JUND gene.
Transcription factor JunD is a protein that in humans is encoded by the JUND gene.
ΔJunD
The dominant negative mutant variant of JunD, known as ΔJunD or Delta JunD, is a potent antagonist of the ΔFosB transcript, as well as other forms of AP-1-mediated transcriptional activity. In the nucleus accumbens, ΔJunD directly opposes many of the neurological changes that occur in addiction (i.e., those induced by ΔFosB). ΔFosB inhibitors (drugs that oppose its action) may be an effective treatment for addiction and addictive disorders. Being an unnatural genetic variant, ΔJunD has not been observed in humans.
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