Lesson plan
MECOM
MDS1 and EVI1 complex locus protein (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. MECOM was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. MECOM is a transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.
Article summary
MDS1 and EVI1 complex locus protein (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. MECOM was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. MECOM is a transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
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