Morphant
≈ 1 min read
Names in other languages
No names in other languages are held for this entry yet.
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
An organism which has been treated with a morpholino antisense oligo to temporarily knock down expression of a targeted gene is called a morphant.
An organism which has been treated with a morpholino antisense oligo to temporarily knock down expression of a targeted gene is called a morphant. ==Background== This term was coined by Prof. Steve Ekker to describe the zebrafish with which he was experimenting; by knocking down embryonic gene expression using Morpholinos, Prof. Ekker "phenocopied" known zebrafish mutations, that is, he raised embryos that had the same morphological phenotype as embryonic zebrafish with specific gene mutations. Prof. Ekker's papers and presentations describing morphant phenocopies of mutant phenotypes, in combination with Prof. Janet Heasman's earlier work with Morpholinos in Xenopus embryos, led to rapid adoption of Morpholino technology by the developmental biology community.
Text derived from https://en.wikipedia.org/w/index.php?oldid=1032207011 under CC BY-SA 4.0; modifications have been made.