MPD-75

MPD-75

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MPD-75, also known as 1-methyl-N-pyrrolidyllysergamide or as 1-methyllysergic acid pyrrolidide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is the 1-methyl derivative of lysergic acid pyrrolidide (LA-Pyr; LPD-824) and the N-pyrrolidide analogue of 1-methyl-LSD (MLD-41). Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed.

Use and effects

MPD-75 was evaluated in humans and was found to produce partial LSD-like effects. It was reported to have had a faster onset and shorter duration compared to LSD. MPD-75 showed less than 5% of the potency of LSD in producing LSD-like effects, with a required dose of >20 μg/kg or >1.6 mg orally. According to another source however, MPD-75 had 7% of the potency of LSD in humans. For comparison, LA-Pyr (LPD-824) had approximately 10% of the potency of LSD and had more full LSD-like effects, while 1-methyl-LSD (MLD-41) had 33% of the potency of LSD and likewise produced full LSD-like effects.

Interactions

Pharmacology

Pharmacodynamics

In animal studies, MPD-75 had 4% of the toxicity of LSD in rabbits (presumably in terms of ), 0% of its pyretogenic activity in rabbits, and 130% of its antiserotonergic activity in the isolated rat uterus.

History

MPD-75 was first described in the scientific literature by Albert Hofmann and colleagues by 1957. It has not been encountered as a designer drug as of 2020.

References

External links

MPD-75 - Isomer Design

Text derived from https://en.wikipedia.org/w/index.php?oldid=1337927189 under CC BY-SA 4.0; modifications have been made.