Lesson plan

Mtcl1

Microtubule cross-linking factor 1, also known as Suppressor of glucose autophagy associated 2, is a protein that in humans is encoded by the MTCL1 gene (previously SOGA2, CCDC165, or KIAA0802). SOGA2 has two human paralogs, SOGA1 and SOGA3. In humans, the gene coding sequence is 151,349 base pairs long, with an mRNA of 6092 base pairs, and a protein sequence of 1586 amino acids. The SOGA2 gene is conserved in gorilla, baboon, galago, rat, mouse, cat, and more. There is distant conservation seen in organisms such as zebra finches and anoles. SOGA2 is ubiquitously expressed in humans, with especially high expression in brain (especially the cerebellum and hippocampus), colon, pituitary gland, small intestine, spinal cord, testis and fetal brain.

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Article summary

Microtubule cross-linking factor 1, also known as Suppressor of glucose autophagy associated 2, is a protein that in humans is encoded by the MTCL1 gene (previously SOGA2, CCDC165, or KIAA0802). SOGA2 has two human paralogs, SOGA1 and SOGA3. In humans, the gene coding sequence is 151,349 base pairs long, with an mRNA of 6092 base pairs, and a protein sequence of 1586 amino acids. The SOGA2 gene is conserved in gorilla, baboon, galago, rat, mouse, cat, and more. There is distant conservation seen in organisms such as zebra finches and anoles. SOGA2 is ubiquitously expressed in humans, with especially high expression in brain (especially the cerebellum and hippocampus), colon, pituitary gland, small intestine, spinal cord, testis and fetal brain.

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  1. Summarise the article in your own words. Which single claim would you verify first, and why?
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