Lesson plan
NSD3
Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the NSD3 gene. This gene is related to the Wolf–Hirschhorn syndrome candidate-1 gene (NSD2) and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. The NSD3 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis.
Article summary
Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the NSD3 gene. This gene is related to the Wolf–Hirschhorn syndrome candidate-1 gene (NSD2) and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. The NSD3 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.