Lesson plan
OSER1
OSER1 (Oxidative Stress Responsive Serine Rich 1), or Chromosome 20 open reading frame 111, C20orf111, is the hypothetical protein that in humans is encoded by the OSER1 gene. OSER1/C20orf111 is also known as Perit1 (peroxide inducible transcript 1), HSPC207, and dJ1183I21.1. It was originally located using genomic sequencing of chromosome 20. The National Center for Biotechnology Information, or NCBI, shows that it is located at q13.11 on chromosome 20, however the genome browser at the University of California-Santa Cruz (UCSC) website shows that it is at location q13.12, and within a million base pairs of the adenosine deaminase locus. It was also found to have an increase in expression in cells undergoing hydrogen peroxide( )-induced apoptosis. After analyzing the amino acid content of OSER1, it was found to be rich in serine residues.
Article summary
OSER1 (Oxidative Stress Responsive Serine Rich 1), or Chromosome 20 open reading frame 111, C20orf111, is the hypothetical protein that in humans is encoded by the OSER1 gene. OSER1/C20orf111 is also known as Perit1 (peroxide inducible transcript 1), HSPC207, and dJ1183I21.1. It was originally located using genomic sequencing of chromosome 20. The National Center for Biotechnology Information, or NCBI, shows that it is located at q13.11 on chromosome 20, however the genome browser at the University of California-Santa Cruz (UCSC) website shows that it is at location q13.12, and within a million base pairs of the adenosine deaminase locus. It was also found to have an increase in expression in cells undergoing hydrogen peroxide( )-induced apoptosis. After analyzing the amino acid content of OSER1, it was found to be rich in serine residues.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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