OvaScience
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OvaScience was a publicly traded biotechnology company, focused on female infertility. It was founded in 20111 by Michelle Dipp, Richard Aldrich, Christoph Westphal, Jonathan Tilly, and David Sinclair and is based on scientific work done by Tilly concerning mammalian oogonial stem cells (OSCs) and work on mitochondria by Sinclair. Tilly's work was expectedly met with skepticism, as it warranted a paradigm-shift. The existence and functional potential of mammalian OSCs remains highly controversial, and the prevailing scientific consensus has not accepted Tilly's proposed paradigm shift. While some allied research groups have reported isolating OSCs using cell-sorting techniques—often relying on the DDX4 protein as a surface marker—independent reproduction of the generation of functional oocytes has been heavily contested. Independent validation studies have shown that cells isolated using these methods do not actually express DDX4 on their surface and lack true germline identity, suggesting that the initial isolation protocols were based on methodological artifacts.
OvaScience was a publicly traded biotechnology company, focused on female infertility. It was founded in 2011 by Michelle Dipp, Richard Aldrich, Christoph Westphal, Jonathan Tilly, and David Sinclair and is based on scientific work done by Tilly concerning mammalian oogonial stem cells (OSCs) and work on mitochondria by Sinclair. Tilly's work was expectedly met with skepticism, as it warranted a paradigm-shift. The existence and functional potential of mammalian OSCs remains highly controversial, and the prevailing scientific consensus has not accepted Tilly's proposed paradigm shift. While some allied research groups have reported isolating OSCs using cell-sorting techniques—often relying on the DDX4 protein as a surface marker—independent reproduction of the generation of functional oocytes has been heavily contested. Independent validation studies have shown that cells isolated using these methods do not actually express DDX4 on their surface and lack true germline identity, suggesting that the initial isolation protocols were based on methodological artifacts. ==See also== Mitochondrial replacement therapy ==References== ==External links==
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