--- title: P21 slug: p21 qid: snapshot: enwiki-001369619137 content_hash: license: CC BY-SA 4.0 source: https://en.wikipedia.org/w/index.php?oldid=1369619137 tags: [23118434, 23603337, 31315860, 41932941, 90848606] --- # P21 > [!note] Provenance > Snapshot `enwiki-001369619137` · content root `…` > Derived from · Licensed CC BY-SA 4.0 p21 Cip1 (alternatively p21 Waf1 ), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest. This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans. p21 Cip1 (alternatively p21 Waf1 ), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest. This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.