PALS2
≈ 2 min read
Names in other languages
No names in other languages are held for this entry yet.
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
Protein PALS2 is a protein that in humans is encoded by the PALS2 gene (previously MPP6). Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1), ZO1-like (see TJP1), p55-like (see MPP1), and LIN2-like (see CASK), based on their size and the presence of additional domains. PALS2/MPP6 is a member of the p55-like MAGUK subfamily.
Protein PALS2 is a protein that in humans is encoded by the PALS2 gene (previously MPP6). Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1), ZO1-like (see TJP1), p55-like (see MPP1), and LIN2-like (see CASK), based on their size and the presence of additional domains. PALS2/MPP6 is a member of the p55-like MAGUK subfamily.
References
Further reading
Text derived from https://en.wikipedia.org/w/index.php?oldid=1371338562 under CC BY-SA 4.0; modifications have been made.