Lesson plan
Pdlim3
Actin-associated LIM protein (ALP), also known as PDZ and LIM domain protein 3, is a protein that in humans is encoded by the PDLIM3 gene. ALP is highly expressed in cardiac and skeletal muscle, where it localizes to Z-discs and intercalated discs. ALP functions to enhance the crosslinking of actin by alpha-actinin-2 and also appears to be essential for right ventricular chamber formation and contractile function.
Article summary
Actin-associated LIM protein (ALP), also known as PDZ and LIM domain protein 3, is a protein that in humans is encoded by the PDLIM3 gene. ALP is highly expressed in cardiac and skeletal muscle, where it localizes to Z-discs and intercalated discs. ALP functions to enhance the crosslinking of actin by alpha-actinin-2 and also appears to be essential for right ventricular chamber formation and contractile function.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
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