PGAP6
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Post-GPI attachment to proteins factor 6 is an enzyme that in humans is encoded by the PGAP6 gene (previously TMEM8A). The PGAP6 protein that acts as a phospholipase A2 as part of the GPI-anchor maturation process.
Post-GPI attachment to proteins factor 6 is an enzyme that in humans is encoded by the PGAP6 gene (previously TMEM8A). The PGAP6 protein that acts as a phospholipase A2 as part of the GPI-anchor maturation process. The gene encodes a protein also called TMEM8A. This protein in 771 amino acids in length but has been shown to have a signal peptide from amino acid 1 to 34; the mature form of the protein is only 737 amino acids in length. The precursor form with signal peptide intact has a molecular weight of 84.780 kilodaltons and the mature form with the signal peptide cleaved has a molecular weight of 81.624 kilodaltons TMEM8A has an isoelectric point of the mature form of pI=7.3.
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