Lesson plan

Plithotaxis

In cellular biology, plithotaxis ( ) is the tendency for each individual cell within a monolayer to migrate along the local orientation of the maximal principal stress, or equivalently, minimal intercellular shear stress. Plithotaxis requires force transmission across many cell-cell junctions and therefore is an emergent property of the cell group. Plithotaxis is found to hold at the level of both a subcellular grid point and an individual cell of a confluent monolayer, and the stresses must be tensile.

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Article summary

In cellular biology, plithotaxis ( ) is the tendency for each individual cell within a monolayer to migrate along the local orientation of the maximal principal stress, or equivalently, minimal intercellular shear stress. Plithotaxis requires force transmission across many cell-cell junctions and therefore is an emergent property of the cell group. Plithotaxis is found to hold at the level of both a subcellular grid point and an individual cell of a confluent monolayer, and the stresses must be tensile.

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Discussion questions

  1. Summarise the article in your own words. Which single claim would you verify first, and why?
  2. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
  3. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

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Key claims and bibliography are generated from the same tracked claims and sources as the article page.