Lesson plan
PMHC cellular microarray
PMHC cellular microarrays are a type of cellular microarray that has been spotted with pMHC complexes peptide-MHC class I or peptide-MHC class II. These biochips can be used to interrogate immune cells, particularly antigen-specific T cells, from clinical samples for what they are capable of recognizing. They can also be co-spotted with other molecules, such as antibodies that capture cytokines, allowing for high-throughput functional analysis of the captured T cells. Molecules spotted on a pMHC cellular microarray can be classified as capture molecules, detector molecules and effector molecules. They were developed by Daniel Chen, Yoav Soen, Dan Kraft, Pat Brown and Mark Davis at Stanford University Medical Center.
Article summary
PMHC cellular microarrays are a type of cellular microarray that has been spotted with pMHC complexes peptide-MHC class I or peptide-MHC class II. These biochips can be used to interrogate immune cells, particularly antigen-specific T cells, from clinical samples for what they are capable of recognizing. They can also be co-spotted with other molecules, such as antibodies that capture cytokines, allowing for high-throughput functional analysis of the captured T cells. Molecules spotted on a pMHC cellular microarray can be classified as capture molecules, detector molecules and effector molecules. They were developed by Daniel Chen, Yoav Soen, Dan Kraft, Pat Brown and Mark Davis at Stanford University Medical Center.
Key claims
No claims recorded.
Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
No sources recorded.
Key claims and bibliography are generated from the same tracked claims and sources as the article page.