PRKCE
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Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. PKCε is clinically significant in that it is a central player in cardioprotection against ischemic injury and in the development of cardiac hypertrophy.
Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. PKCε is clinically significant in that it is a central player in cardioprotection against ischemic injury and in the development of cardiac hypertrophy.
Substrates and interactions
PKC-epsilon has a wide variety of substrates, including ion channels, other signalling molecules and cytoskeletal proteins. PKC-epsilon has been shown to interact with: ACTA1, COPB2, CFTR, KRT1, GNB2L1, MYH9, VDAC1, and YWHAZ.
Notes
Text derived from https://en.wikipedia.org/w/index.php?oldid=1374864846 under CC BY-SA 4.0; modifications have been made.