Lesson plan
PSKH2
Protein Serine/threonine-protein kinase H2 is a Ser/Thr protein pseudokinase that is encoded by the PSKH2 gene, and forms part of the CAMK subfamily of protein kinases. Homologues of PSKH2 are absent in rodents, but a PSKH2-like sequence is present in most vertebrate genomes. PSKH2 does not bind to ATP, nor does it phosphorylate any known substrate in cells, simplistically because it lacks the catalytic Asp residue in the HRD motif. The PSKH2 protein interactome is complex, and involves a number of membrane-associated proteins alongside the HSP90 Cdc37 molecular chaperone complex. PSKH2 exhibits significant sequence homology to the catalytically active Ser/Thr kinase PSKH1.
Article summary
Protein Serine/threonine-protein kinase H2 is a Ser/Thr protein pseudokinase that is encoded by the PSKH2 gene, and forms part of the CAMK subfamily of protein kinases. Homologues of PSKH2 are absent in rodents, but a PSKH2-like sequence is present in most vertebrate genomes. PSKH2 does not bind to ATP, nor does it phosphorylate any known substrate in cells, simplistically because it lacks the catalytic Asp residue in the HRD motif. The PSKH2 protein interactome is complex, and involves a number of membrane-associated proteins alongside the HSP90 Cdc37 molecular chaperone complex. PSKH2 exhibits significant sequence homology to the catalytically active Ser/Thr kinase PSKH1.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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